| CAS NO: | 62499-27-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 286.28 |
|---|---|
| Formula | C13H18O7 |
| CAS No. | 62499-27-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 50 mg/mL (174.7 mM) |
| Water: <1 mg/mL | |
| Ethanol: <1 mg/mL | |
| Other info | Chemical Name: 4-(hydroxymethyl)phenyl β-D-glucopyranoside InChi Key: PUQSUZTXKPLAPR-UJPOAAIJSA-N InChi Code: InChI=1S/C13H18O7/c14-5-7-1-3-8(4-2-7)19-13-12(18)11(17)10(16)9(6-15)20-13/h1-4,9-18H,5-6H2/t9-,10-,11+,12-,13-/m1/s1 SMILES Code: O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OC2=CC=C(CO)C=C2 |
| Synonyms | Gastrodine |
| In Vitro | In vitro activity: Gastrodin is the most important and effective ingredient extracted from Chinese natural herbal Gastrodia elata. Gastrodin (30, 40, and 60 mM) significantly attenuates levels of neurotoxic proinflammatory mediators and proinflammatory cytokines by inhibition of the NF-kappaB signaling pathway and phosphorylation of MAPKs in LPS-stimulated microglial cells. However, It also upregulates the phosphatidylinositol 3-kinase (PI3-K)/Akt signaling, resulting in the inhibitory effects NF-kappaB and MAPKs activation in H9c2 cardiomyocytes. Cell Assay: Retinas are collected at day 14 postoperatively, following treatment with normal saline (NS) or various doses of Gastrodin. The mRNA expression levels of TNF-α and iNOS are determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). |
|---|---|
| In Vivo | Gastrodin at 5 mg/kg can improve cycloheximide- and apomorphine-induced amnesia, but not scopolamine-induced acquisition impairment in rats. Thus, GAS can facilitate memory consolidation and retrieval, but not acquisition. |
| Animal model | Rats |
| Formulation & Dosage | 5 mg/kg |
| References | PLoS One. 2011;6(7):e21891; Biochem Pharmacol. 2013 Apr 15;85(8):1124-33; J Ethnopharmacol. 1997 Mar;56(1):45-54. |
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