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CVT-10216
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CVT-10216图片
CAS NO:1005334-57-5
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
CVT-10216, an isoflavone compound, is a novel, highly potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) with IC50s of 29 and 1300 nM for ALDH2 and ALDH1, respectively. CVT-10216 increases acetaldehyde after alcohol gavage and inhibits 2-bottle choice alcohol intake in heavy drinking rodents, including deprivation-induced drinking. Moreover, CVT-10216 also prevents operant self-administration and eliminates cue-induced reinstatement of alcohol seeking even when alcohol is not available (i.e., no acetaldehyde). Alcohol stimulates DA release in the NAc, which is thought to contribute to increased drinking and relapse in alcoholism. CVT-10216 prevents alcohol-induced increases in NAc DA without changing basal levels.