CFI-402257 (CFI402257) is a novel, highly potent, orally bioavailable and selective inhibitor of TTK protein kinase (also known as Monopolar spindle 1 [Mps1]) activity with potential anticancer activity. It inhibits TTK with a Ki of 0.1 nM. TTK is an essential chromosomal regulator overexpressed in aneuploid tumors, and is important in regulating cell growth. High TTK levels correlate with a high tumor grade11 and poor patient outcomes. TTK inhibition are associated with a disabled mitotic checkpoint, resulting in chromosome segregation errors, aneuploidy, and cell death.

纯度：≥98%

CAS：1610759-22-2