CAS NO: | 1011301-29-3 |
规格: | ≥98% |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
Molecular Weight (MW) | 491.09 |
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Formula | C25H35ClN4O2S |
CAS No. | 1011301-29-3 (HCl); |
Storage | -20℃ for 3 years in powder form |
-80℃ for 2 years in solvent | |
Solubility (In vitro) | DMSO: ≥ 49 mg/mL |
Water: N/A | |
Ethanol: N/A | |
Solubility (In vivo) | Tenovin-6 HCl; Tenovin 6 HCl; Tenovin6 HCl |
General | Tenovin-6 is a more water-soluble analog of tenovin-1. Tenovin-6 acts through inhibition of the protein-deacetylating activities of SirT1 and SirT2. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 of 21 μM, 10 μM, and 67 μM, respectively. |
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Animal model | ARN8 melanoma cells were injected into the flank of SCID mice and allowed to develop into tumors. |
Formulation | |
Dosages | 50 mg/kg |
Administration | i.p. |
Reference | [1] Lain S, et al. Cancer Cell, 2008, 13(5), 454-463. |