Description: Lomibuvir sodium (S-1480; VCH-222; VX-222) is a novel, potent and selective non-nucleoside inhibitor/NNI of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase with IC50s in the range of 0.94-1.2 μM. It has been investigatedin clinical trials for the treatment of chronic HCV and chronic HCV infections. ) is a novel, potent and selective non-nucleoside inhibitor/NNI of hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase with IC50s of 0.94-1.2 μM, it has been investigatedin clinical trials for the treatment of chronic HCV and chronic HCV infections.
References: Antimicrob Agents Chemother. 2012 Feb;56(2):830-7; J Hepatol, 2009, 50(Suppl 1), S341-S342.