CPYPP is a small-molecule inhibitor of DOCK guanine nucleotide exchange factors (GEFs). CPYPP may have some efficacy in treating NET-mediated inflammatory disorders. References: Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Coté JF, Sumimoto H, Fukui Y. DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation. J Immunol. 2014 Dec 1;193(11):5660-7. doi: 10.4049/jimmunol.1400885. Epub 2014 Oct 22. PubMed PMID: 25339677; PubMed Central PMCID: PMC4640904.
纯度:≥98%
CAS:310460-39-0