Description: Guanabenz (also known as WY-8678) is a potent and selective agonist of α2a-adrenergic receptor, α2b-adrenergic receptor and α2c-adrenergic receptor with pEC50 of 8.25, 7.01 and ~5, respectively. Guanabenz at a concentration of 30 μM causes a time-dependent loss of nNOS-activity, which is present in cytosol prepared from rat nNOS transfected HEK 293 cells, with a Ki of 1 μM. Guanabenz can induce a concentration-dependent loss of nNOS activity.

References: J Biol Chem. 2000 Jan 28;275(4):2376-80; J Pharmacol Exp Ther. 1970 Feb;171(2):276-87.

纯度：≥98%

CAS：5051-62-7