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SLMP53-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SLMP53-1图片
CAS NO:1643469-17-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
SLMP53-1 是一种具有良好抗肿瘤活性的野生型和突变型 p53 再激活剂。 SLMP53-1 介导癌细胞葡萄糖代谢的重编程。 SLMP53-1 减少血管生成,减少内皮细胞管的形成和血管内皮生长因子 (VEGF) 的表达水平。
Cas No.1643469-17-3
分子式C20H18N2O2
分子量318.37
溶解度DMSO : 250 mg/mL (785.25 mM; ultrasonic and warming and heat to 80°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

SLMP53-1 is a wild-type and mutant p53 reactivator with promising antitumor activity. SLMP53-1 mediates the reprograming of glucose metabolism in cancer cells. SLMP53-1 depletes angiogenesis, decreasing endothelial cell tube formation and vascular endothelial growth factor (VEGF) expression levels[1][2].

[1]. Gomes S, et al. SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma. Cancers (Basel). 2019 Aug 10;11(8):1151.
[2]. Ramos H, et al. SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner. Int J Mol Sci. 2020 Jan 17;21(2):596.