HIF-1α-IN-2 是一种有效的 HIF-1α 抑制剂，具有抗癌作用，在 MDA-MB-231 和 MiaPaCa-2 细胞 IC50 中分别为 28 nM 和 15 nM。HIF-1α-IN-2 通过阻断转录和蛋白质翻译抑制来 HIF-1α 的表达。
| Cas No. | 2762315-06-8 |
| 分子式 | C21H19N3OS |
| 分子量 | 361.46 |
| 储存条件 | 4°C, away from moisture and light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | HIF-1α-IN-2 is an effectiveHIF-1αinhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation[1]. HIF-1α-IN-2 (compound 7f) (5 μM; 72h) suppresses the viability of MDA-MB-231 and MiaPaCa-2 cells with IC50s of 28 nM and 15 nM, respectively[1].
HIF-1α-IN-2 (0-1 μM; 72h) suppresses the expression of HIF-1α and VEGF with dose-dependent effect[1].
HIF-1α-IN-2 (0.25, 0.5, and 1 µM; 16-24h) can significantly inhibit the migration of MDA-MD-231 cells by 56% (0.25 µM), 83% (0.5 µM), and 85% (1 µM), respectively, and also noted in MiaPaCa-2 cells, which demonstrates the unique anti-migration effect of HIF-1α-IN-2[1].
HIF-1α-IN-2 (0-1 μM; 72h) suppresses HIF-1α mRNA levels in MDA-MB-231 cells under hypoxia[1]. Cell Viability Assay | Cell Line: | MDA-MB-231 cells, MiaPaCa-2 cells[1] | | Concentration: | 5 μM | | Incubation Time: | 72 hours | | Result: | Suppressed the viability of these two cell lines with IC50of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively. |
Cell Viability Assay | Cell Line: | MDA-MB-231 cells, MiaPaCa-2 cells[1] | | Concentration: | 5 μM | | Incubation Time: | 72 hours | | Result: | Suppressed the viability of these two cell lines with IC50of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively. |
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