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NDI-034858
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NDI-034858图片
CAS NO:2272904-53-5
包装:5mg
市场价:13500元

产品介绍
NDI-034858 是一种 Tyk2 抑制剂,靶向 Tyk2 的 JH2 结构域,结合常数 Kd <200 pM。
Cas No.2272904-53-5
分子式C23H24N8O3
分子量460.49
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NDI-034858 is aTYK2inhibitor, targetTYK2 JH2domain with binding constant Kdof <200 pM[1].

NDI-034858 (compound I-908) (10 μM) exhibits inhibitory effect on Tyk2 and JAK by targeting Tyk2 JH1 and JAK JH1 domain with inhibition rates <50%, respectively[1].
NDI-034858 inhibits phosphorylation induction of heterodimer complex Tyk2 /JAK2-mediated IL-12 (1.7 ng/mL) effect, with IC50value of <0.1 μM in human peripheral blood mononuclear cell[1].