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AS-85
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AS-85图片
CAS NO:2323623-80-7
包装:10mg
市场价:8505元

产品介绍
AS-85 是一种有效的 ASH1L 抑制剂 (IC50=0.6 µM) 具有抗白血病活性。AS-85 与 ASH1L SET 域结合,Kd 值为 0.78 µM。
Cas No.2323623-80-7
分子式C26H28F3N5O3S2
分子量579.66
溶解度DMSO : 100 mg/mL (172.51 mM; Need ultrasonic)
储存条件Store at -20°C, away from moisture and light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AS-85 is a potentASH1L histone methyltransferaseinhibitor (IC50=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with theKdvalue of 0.78 µM[1].

AS-85 inhibits the growth of leukemia cells (MV4;11, MOLM13, and KOPN8) harboring differentMLL1translocations, with GI50values ranging from 5 µM to 25 µM, and demonstrates no effect in K562 leukemia cells without MLL1 translocations[1].