CAS NO: | 2323623-80-7 |
包装: | 10mg |
市场价: | 8505元 |
Cas No. | 2323623-80-7 |
分子式 | C26H28F3N5O3S2 |
分子量 | 579.66 |
溶解度 | DMSO : 100 mg/mL (172.51 mM; Need ultrasonic) |
储存条件 | Store at -20°C, away from moisture and light |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | AS-85 is a potentASH1L histone methyltransferaseinhibitor (IC50=0.6 µM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with theKdvalue of 0.78 µM[1]. AS-85 inhibits the growth of leukemia cells (MV4;11, MOLM13, and KOPN8) harboring differentMLL1translocations, with GI50values ranging from 5 µM to 25 µM, and demonstrates no effect in K562 leukemia cells without MLL1 translocations[1]. |