您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > TFMB-(S)-2-HG
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
TFMB-(S)-2-HG
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TFMB-(S)-2-HG图片
CAS NO:1445703-64-9
包装:5mg
市场价:3150元

产品介绍
TFMB-(S)-2-HG 是 5'-甲基胞嘧啶羟化酶 TET2 的有效抑制剂。TFMB-(S)-2-HG 也抑制 EglN 脯氨酰羟化酶。TFMB-(S)-2-HG 具有研究急性髓性白血病 (AML) 的潜力。
Cas No.1445703-64-9
分子式C13H11F3O4
分子量288.22
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

TFMB-(S)-2-HG is a potent inhibitor of the 5'-methylcytosine hydroxylase TET2. TFMB-(S)-2-HG also inhibits the EglN prolyl hydroxylases. TFMB-(S)-2-HG has the potential for the research of acute myeloid leukemia (AML)[1].

[1]. Losman JA, et al. (R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible. Science. 2013;339(6127):1621-1625.