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Cu-ATSP
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cu-ATSP图片
CAS NO:68341-12-8
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Cu-ATSP 是一种有效的铁死亡细胞死亡抑制剂，其效力几乎是 CuATSM 的 20 倍。
Cas No.68341-12-8
Canonical SMILESCC1=[N-]2N=C(NC3=CC=CC=C3)S[Cu+2]42SC(NC5=CC=CC=C5)=N[N-]4=C1C
分子式C18H18CuN6S2
分子量446.1
溶解度DMF: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cu-ATSP is a copper-containingbis(thiosemicarbazone) complex with ferroptosis inhibitory activity.1It traps peroxyl radicals in a cell-free assay when used at a concentration of 6 µM. Cu-ATSP inhibits ferroptosis induced by (1S,3R)-RSL3 in Pfa1 mouse embryonic fibroblasts (MEFs) and HT22 mouse hippocampal cells (EC50s = 8.5 and 16 nM, respectively). It increases intracellular copper levels but, unlike thebis(thiosemicarbazone) complexes Cu-CQ2 and CuNC2, does not reduce amyloid-β (1-40) (Aβ40) levels in CHO cells overexpressing amyloid precursor protein (APP).2

1.Zilka, O., Poon, J.-F., and Pratt, D.A.Radical-trapping antioxidant activity of copper and nickel bis(thiosemicarbazone) complexes underlies their potency as inhibitors of ferroptotic cell deathJ. Am. Chem. Soc.143(45)19043-19057(2021) 2.Donnelly, P.S., Caragounis, A., Du, T., et al.Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-β peptideJ. Biol. Chem.283(8)4568-4577(2008)