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O-Demethyl Apremilast
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
O-Demethyl Apremilast图片
CAS NO:1384441-38-6
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
An active metabolite of apremilast
Cas No.1384441-38-6
别名阿普斯特杂质
Canonical SMILESCS(C[C@H](C1=CC(OCC)=C(C=C1)O)N2C(C3=C(NC(C)=O)C=CC=C3C2=O)=O)(=O)=O
分子式C21H22N2O7S
分子量446.5
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:2): 0.3 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 µM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3

1.Hoffmann, M., Kumar, G., Schafer, P., et al.Disposition, metabolism and mass balance of [14C]apremilast following oral administrationXenobiotica41(12)1063-1075(2011) 2.Lu, Y., Shen, X., Hang, T., et al.Identification and characterization of process-related substances and degradation products in apremilast: Process optimization and degradation pathway elucidationJ. Pharm. Biomed. Anal.14170-78(2017) 3.Bhole, R.P., Naksakhare, S.R., and Bonde, C.G.A stability indicating HPTLC method for apremilast and identification of degradation products using MS/MSJ. Pharm. Sci. & Res.11(5)1861-1869(2019)