Zilovertamab

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Zilovertamab

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	5mg
市场价:	11250元

产品介绍

Zilovertamab (UC-961) 是一种人源化抗 ROR1 单克隆抗体，可阻断 Wnt5a 诱导的 ROR1 信号通路。

别名

UC-961; Cirmtuzumab

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

Zilovertamab (UC-961) is a humanised monoclonal antibody againstROR1that blocks Wnt5a-induced ROR1 signalling^[1].

Zilovertamab (25 and 50 µg/mL; 72 h) inhibits high-grade serous ovarian cancer (HGSOC) cell proliferation^[1].
Zilovertamab (50 µg/mL; 72 h) down-regulates ROR1 expression levels in CaOV3 at the transcriptional level^[1].

Cell Proliferation Assay^[1]

Cell Line:	CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:	25 and 50 µg/mL
Incubation Time:	72 hours
Result:	Reduced the proliferation of CaOV3, CaOV3CisR and PEO1.

Western Blot Analysis^[1]

Cell Line:	CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration:	50 µg/mL
Incubation Time:	72 hours
Result:	Down-regulated ROR1 expression levels in CaOV3 at the transcriptional level.