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Enbezotinib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Enbezotinib图片
CAS NO:2359649-81-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Enbezotinib 是一种 RET 的抑制剂,可抑制 RET 的自磷酸化。Enbezotinib 可用于癌症的研究。
Cas No.2359649-81-1
分子式C21H21FN6O3
分子量424.43
溶解度DMSO : 100 mg/mL (235.61 mM; ultrasonic and warming and heat to 80°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Enbezotinib, an inhibitor of RET, can inhibit the RET autophosphorylation. Enbezotinib can be used for the research of cancer[1].

Enbezotinib (compound 5) (0.3-300 nM) inhibits p-RET (y905) in RET-driven cells[1].

Enbezotinib (compound 5) (2-5 mg/kg; twice daily for 27 days) decreases tumor size in mice[1].

[1]. ROGERS EW, et, al. Macrocyclic compounds for treating disease. WO2019126121A1.