您好，欢迎来到试剂信息网！ [登录] [免费注册]
试剂信息网
发布求购
位置：首页 > 产品库 > Fludarabine triphosphate trisodium
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
Fludarabine triphosphate trisodium
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Fludarabine triphosphate trisodium图片
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
100mg电议

产品介绍
Fludarabine triphosphate (F-ara-ATP) trisodium 是 Fludarabine 的活性代谢物，是一种有效的、非竞争性的、特异性的DNA引发酶 (DNA primase) 抑制剂，其 IC50 为 2.3 μM，Ki 为 6.1 μM。Fludarabine triphosphate trisodium 通过阻断 DNA 引发酶和引物 RNA 形成抑制 DNA 合成 (DNA synthesis)。Fludarabine triphosphate trisodium 可抑制核糖核苷酸还原酶和DNA聚合酶，最终导致细胞凋亡 (apoptosis)。$
别名F-ara-ATP trisodium
分子式C10H12FN5Na3O13P3
分子量591.12
溶解度H2O : 250 mg/mL (422.93 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

IC50: 2.3 ± 0.3 μM (DNA primase); Ki: 6.1 ± 0.3 μM (DNA primase)[1]

Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite ofFludarabine, is a potent, noncompetitive and specific inhibitor ofDNA primase, with anIC50of 2.3 μM and aKiof 6.1 μM. Fludarabine triphosphate trisodium inhibitsDNA synthesisby blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellularapoptosis[1][2].

Fludarabine triphosphate trisodium is a more potent inhibitor of the polydeoxythymidylate primase activity than of the DNA polymerase α/δ activities present in the supernatants of CCRF-CEM cells[1].
Fludarabine triphosphate trisodium (10-50 μM) inhibits the incorporation of ATP into primer RNA and dTTP into DNA to a similar extent[1].

$