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AzddMeC
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
AzddMeC图片
CAS NO:87190-79-2
包装与价格：
包装价格(元)
10mg电议
25mg电议

产品介绍
AzddMeC (CS-92) 是一种抗病毒核苷类似物，也是一种有效的，选择性的，具有口服活性的 HIV-1 逆转录酶和 HIV-1 复制的抑制剂。在感染 HIV-1 的人类 PBM 细胞和感染 HIV-1 的人类巨噬细胞中，AzddMeC 的 EC50 值分别为 9 nM 和 6 nM。
Cas No.87190-79-2
别名CS-92
分子式C10H14N6O3
分子量266.26
溶解度DMSO : 200 mg/mL (751.15 mM; Need ultrasonic)
储存条件4°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

AzddMeC (CS-92) is an antiviralnucleoside analogueand a potent potent, selective and orally activeHIV-1 reverse transcriptaseandHIV-1 replicationinhibitor. InHIV-1-infected human PBM cells andHIV-1-infected human macrophages, theEC50values of AzddMeC are 9 nM and 6 nM, respectively[1][2].

AzddMeC (CS-92) is also effective against HIV-2 in lymphocytes. The replication of Friend murine virus is only weakly inhibited, and no effect is observed against HSV type 1 and type 2 and coxsackievirus B4. The interaction of the 5'-triphosphate of AzddMeC with HIV-1 reverse transcriptase indicated competitive inhibition (the inhibition constant, Kis, is 9.3 nM)[1].

The pharmacokinetics of AzddMeC are characterized following intravenous and oral administration of 60 mg/kg of the compound to male rhesus monkeys. 3'-azido-3'-deoxythymidine (AZT) is a major metabolite of AzddMeC in monkeys. AzddMeC concentrations in serum declined rapidly in a biexponential fashion with the terminal half-life ranging from 0.5 to 1.3 hr. Renal excretion of unchanged nucleoside and metabolic deamination yielding AZT are the primary routes of AzddMeC clearance. The oral bioavailability is 26%[2].