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Grepafloxacin hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Grepafloxacin hydrochloride图片
CAS NO:161967-81-3
包装:10mg
市场价:13050元

产品介绍
Grepafloxacin (OPC-17116) hydrochloride 是一种口服活性氟喹诺酮类抗生素 (antibiotic)，对包括肺炎链球菌在内的社区获得性呼吸道病原体具有有效活性。Grepafloxacin hydrochloride 具有较高的组织渗透性和良好的药效学特性。
Cas No.161967-81-3
别名OPC-17116 hydrochloride; dl-Grepafloxacin hydrochloride
分子式C19H23ClFN3O3
分子量395.86
溶解度H2O : ≥ 13.33 mg/mL (33.67 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Grepafloxacin (OPC-17116) hydrochloride is an oral actively fluoroquinoloneantibioticwith potent activity against community-acquired respiratory pathogens includingStreptococcus pneumonia. Grepafloxacin hydrochloride has high tissue penetration and a promising pharmacodynamic profile[1][2][3][4].

Grepafloxacin (OPC-17116; 0-1 mg/L; 14-21 d) hydrochloride has antibiotic activity with a MIC value of ≤ 0.006 mg/L forE. colistrain[1].
Grepafloxacin (0-1 mg/L; 3 h) hydrochloride has antimicrobial activity against mycobacteria in macrophages with a MIC value of 0.5 mg/L forM. avium[1].
Grepafloxacin hydrochloride exhibits potent in vitro antibacterial activity against Gram-positive bacteria such as Streptococcus pneumoniae and high in vivo efficacy on the experimental systemic infections caused by the Gram-positive and -negative bacteria tested[4].

Grepafloxacin (OPC-17116; 200 mg/kg; p.o.; Balb/c mice) hydrochloride displays good safety profile in terms of phototoxicity[2].
Grepafloxacin (25-200 mg/kg; p.o.; 5 days/week for 4 weeks; female C57BL6/J-Lyst bg-J/ mice/beige mice) hydrochloride has modest activities in both intranasal (IN) infection and intravenous (IV)Mycobacterium aviuminfection models[3].