您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > RR-11a analog
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
RR-11a analog
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
RR-11a analog图片
CAS NO:685543-66-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
RR-11a analog 是一种有效且不可逆的 Schistosoma mansoni legumain 抑制剂。其 IC50 为 31 nM。RR-11a analog 是 aza-Asn 的衍生物和 aza-peptide Michael 的受体。
Cas No.685543-66-2
分子式C22H29N5O8
分子量491.49
溶解度DMSO : 125 mg/mL (254.33 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

RR-11a analog is a potent and irreversible inhibitor of Schistosoma mansoni legumain, with an IC50 of 31 nM. RR-11a analog is an aza-Asn derivative and aza-peptide Michael acceptor[1][2].

RR-11a analog has a half-live of 3-10 min[2].

[1]. GÖtz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32.
[2]. Ekici OD, et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47(8):1889-92.