| CAS NO: | 878581-60-3 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 878581-60-3 |
| Canonical SMILES | O=C(C1=NC=CN=C1)NC2=CC=CC3=C2N=CC=C3 |
| 分子式 | C14H10N4O |
| 分子量 | 250.3 |
| 溶解度 | DMF: 5 mg/ml,DMSO: 2 mg/ml |
| 储存条件 | -20буC |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | QN523 is an anticancer agent.1It is cytotoxic to MiaPaCa-2, PANC-1, and BxPC-3 pancreatic cancer cells (IC50s = 0.11, 0.5, and 3.3 µM, respectively). QN523 (0.5 µM) induces cell cycle arrest at the S phase in MiaPaCa-2 cells. It increases levels of the endoplasmic reticulum (ER) stress markers glucose-regulated protein 78 kDa (GRP78), DNA damage inducible transcript 3 (DDIT3), activating transcription factor 3 (ATF3), and growth differentiation factor 15 (GDF15), as well as the autophagy markers WD repeat domain phosphoinositide-interacting protein 1 (WIPI1), GABAAreceptor-associated protein-like 1 (GABARAPL1), and LC3-II in MiaPaCa-2 cells in a concentration-dependent manner. QN523 reduces tumor volume in a MiaPaCa-2 mouse xenograft model. 1.Kuang, Y., Ye, N., Kyani, A., et al.Induction of genes implicated in stress response and autophagy by a novel quinolin-8-yl-nicotinamide QN523 in pancreatic cancerJ. Med. Chem.65(8)6133-6156(2022) |
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