| CAS NO: | 3316-02-7 |
| 包装 | 价格(元) |
| 汎-Stat 10mM (in 1mL Water) | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Cas No. | 3316-02-7 |
| 别名 | NSC37044 |
| 分子式 | C10H8O10S3 |
| 分子量 | 384.36 |
| 溶解度 | Water : 62.5 mg/mL (162.61 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2]. ζ-Stat (0.1-20 µM) shows only 13% inhibition on PKC-Ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1].ζ-Stat (0.1-10 µM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1].ζ-Stat (7 or 10 µM; 24-72?h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2].ζ-Stat (5 µM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1].ζ-Stat (5 µM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1]. [1]. Ratnayake WS, et, al. Oncogenic PKC-Ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-Ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463. |
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