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I-191
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
I-191图片
CAS NO:1690172-25-8
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
I-191 是一种有效选择性的蛋白酶激活受体 2 (PAR2) 拮抗剂。
Cas No.1690172-25-8
分子式C23H26FN5O2
分子量423.48
溶解度DMSO : 8.33 mg/mL (19.67 mM; Need ultrasonic)|Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

I-191 is a potent, selective protease-activated receptor 2 (PAR2) antagonist[1].

I-191 inhibits cytokine production as well as cytokine-related caspase cleavages via ERK1/2 signaling in HT29 colon cancer cells[1].

[1]. Jiang Y, et al. A Potent Antagonist of Protease-Activated Receptor 2 That Inhibits Multiple Signaling Functions in Human Cancer Cells. J Pharmacol Exp Ther. 2018 Feb;364(2):246-257.