| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Canonical SMILES | CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CNC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](C)NC([C@H](CCCCN)NC(CNC([C@@H](N)[C@H](O)C)=O)=O)=O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O.OC(C(F)(F)F)=O |
| 分子式 | C54H84N14O14S • XCF3COOH |
| 分子量 | 1185.4 |
| 溶解度 | Water: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Hemokinin 1 is a tachykinin peptide neurokinin-1 (NK1) receptor agonist.1,2,3,4,5It induces migration of A375 and B16/F10 melanoma cells when used at a concentration of 1 µM, an effect that can be reversed by the NK1receptor antagonist L-732,138 .1Hemokinin 1 (0.001-0.1 µM) promotes the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs).2It induces the production of prostaglandin E2in human colon mucosal and muscle explants.3Intracerebroventricular administration of hemokinin 1 increases the latency to withdrawal in the tail-flick test in mice in a dose-dependent manner.4It decreases mean arterial pressure (MAP) and heart rate in anesthetized rats when administered at doses ranging from 1 to 30 nmol/kg.5 1.Zhang, Y., Li, X., Li, J., et al.Human hemokinin-1 promotes migration of melanoma cells and increases MMP-2 and MT1-MMP expression by activating tumor cell NK1 receptorsPeptides838-15(2016) 2.Song, H., Yin, W., Zeng, Q., et al.Hemokinins modulate endothelium function and promote angiogenesis through neurokinin-1 receptorInt. J. Biochem. Cell Biol.44(9)1410-1421(2012) 3.Dai, L., Perera, D.S., King, D.W., et al.Hemokinin-1 stimulates prostaglandin E2 production in human colon through activation of cyclooxygenase-2 and inhibition of 15-hydroxyprostaglandin dehydrogenaseJ. Pharmacol. Exp. Ther.340(1)27-36(2012) 4.Fu, C.Y., Zhao, Y.L., Dong, L., et al.In vivo characterization of the effects of human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on the modulation of pain in miceBrain Behav. Immun.22(6)850-860(2008) 5.Kong, Z.-Q., Fu, C.-Y., Chen, Q., et al.Cardiovascular responses to intravenous administration of human hemokinin-1 and its truncated form hemokinin-1(4-11) in anesthetized ratsEur. J. Pharmacol.590(1-3)310-316(2008) |
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