Medroxalol

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Medroxalol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:	56290-94-9
包装:	10mg
市场价:	10620元

产品介绍

Medroxalol (RMI81968) 是一种具有口服活性的肾上腺素受体拮抗剂，可阻断 α- 和 β- 肾上腺素受体。Medroxalol 具有抗高血压和血管扩张的活性。

Cas No.

56290-94-9

别名

RMI81968

分子式

C₂₀H₂₄N₂O₅

分子量

372.41

储存条件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

Medroxalol (RMI81968) is an orally activeadrenergic receptorantagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects^[1].

Medroxalol (0.1-10 μM; 20 min) shows α- and β-adrenergic receptor antagonism in isolated rabbit aortic strip^[1].

Cell Viability Assay^[1]

Cell Line:	Isolated rabbit aortic strip
Concentration:	0.1-10 μM
Incubation Time:	20 min
Result:	Showed pA₂values of 6.09 and 7.73 for α-adrenergic receptors and β-adrenergic receptors, respevtively.

Medroxalol (oral gavage; 12.5-50 mg/kg; once daily; 12 d) treatment shows antihypertensive activity in spontaneously hypertensive rats^[1].

Animal Model:	Male spontaneously hypertensive rats (SHR)^[1]
Dosage:	12.5, 25, or 50 mg/kg
Administration:	Oral gavage; 12.5, 25, or 50 mg/kg; once daily; 12 days
Result:	Produced a dose-related fall in blood pressure.