Wnt/β-catenin agonist 3

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

912790-59-1

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

Wnt/β-catenin agonist 3 (compound 98) 是一种 Wnt/β-catenin 信号通路激动剂。Wnt/β-catenin agonist 3 可用于骨质疏松症的研究。

Cas No.

912790-59-1

分子式

C₁₆H₁₅ClN₄O₂

分子量

330.77

溶解度

DMSO : 250 mg/mL (755.81 mM; Need ultrasonic)

储存条件

4°C, protect from light

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

产品描述

Wnt/β-catenin agonist 3 (compound 98) is aWnt/β-cateninsignalling pathway agonist. Wnt/β-catenin agonist 3 can be used for the research of osteoporosis^[1].

Wnt/β-catenin agonist 3 (compound 98; 24 h; HEK293 and SW480 cells) has 54% cell activity at 120 μM concentration compared with the positive control group LiCl (20mM)^[1].
Wnt/β-catenin agonist 3 (30 and 60 μM; 24 h; HEK293 cells) is an activator for β-Catenin and deposits β-catenin^[1].
Wnt/β-catenin agonist 3 (11 μM; 4 d) induces differentiation of ST2 cell line into osteoblasts and calcium deposition^[1].

Western Blot Analysis^[1]

Cell Line:	HEK293 cells
Concentration:	30 and 60 μM
Incubation Time:	24 hours
Result:	Deposited β-catenin in a dose-dependent pattern within cells.