CAS NO: | 2763260-39-3 |
包装: | 10mg |
市场价: | 9000元 |
Cas No. | 2763260-39-3 |
分子式 | C22H12Cl2F3N3O2S |
分子量 | 510.32 |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | NRX-252114 is a potent enhancer of the interaction betweenβ-catenin, and its cognateE3 ligase, SCFβ-TrCP. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with anEC50of 6.5 nM and aKdof 0.4 nM. NRX-252114 induces mutant β-catenin degradation[1]. NRX-252114 enhances the binding of pSer33/S37A β-catenin peptide for β-TrCP with >1500-fold cooperativity, surpassing the affinity of wild-type doubly-phosphorylated peptide. NRX-252114 further enhances the ubiquitylation of pSer33/S37A β-catenin peptide to form long ubiquitin chains[1]. |