| CAS NO: | 1782532-06-2 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Cas No. | 1782532-06-2 |
| Canonical SMILES | O=C1NC(CCN2CCN(CC2)C3=CC(C)=C(C)C=C3)C4=CC=CC=C14.Cl.Cl |
| 分子式 | C22H27N3O • 2HCl |
| 分子量 | 422.4 |
| 溶解度 | DMSO: 100 mM,Water: 50 mM |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PD 168568 is a dopamine D4receptor antagonist (Ki= 8.8 nM).1It is selective for dopamine D4over D2receptors (Ki= 1,842 nM). PD 168568 (3 mg/kg) reverses amphetamine-induced hyperlocomotion in rats. It also inhibits the growth of glioblastoma neural stem cells when used at concentrations of 25 and 50 µM.2 1.Belliotti, T.R., Brink, W.A., Kesten, S.R., et al.Isoindolinone enantiomers having affinity for the dopamine D4 receptorBioorg. Med. Chem. Lett.8(12)1499-1502(1998) 2.Dolma, S., Selvadurai, H.J., Lan, X., et al.Inhibition of dopamine receptor D4 impedes autophagic flux, proliferation, and survival of glioblastoma stem cellsCancer Cell29(6)859-873(2016) |
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