| CAS NO: | 886212-98-2 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
| Cas No. | 886212-98-2 |
| Canonical SMILES | BrCC(N[C@@H](CO)[C@@H](CCCCCCCCCCCCCCC)O)=O |
| 分子式 | C20H40BrNO3 |
| 分子量 | 422.4 |
| 溶解度 | Chloroform: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SABRAC is an inhibitor of acid ceramidase (IC50= 52 nM).1It is selective for acid ceramidase over neutral ceramidase and the cysteine protease papain at 3 µM. SABRAC inhibits acid ceramidase in PC3 MC metastatic prostate cancer cells (IC50=<1 µM), as well as induces accumulation of ceramides in the same cells. It completely inhibits anchorage-independent colony formation but does not induce cytotoxicity in PC3 MC cells when used at a concentration of 5 µM. 1.Camacho, L., Meca-CortÉs, O., Abad, J.L., et al.Acid ceramidase as a therapeutic target in metastatic prostate cancerJ. Lipid Res.54(5)1207-1220(2013) |
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