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Somatostatin-28(human,mouse,rat,porcine,bovine,ovine)(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装:500 µg
市场价:2212元

产品介绍
A cyclic neuropeptide hormone
Canonical SMILES[H]N[C@@H](CO)C(N[C@H](C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N1CCC[C@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N2CCC[C@H]2C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CCCCN)C(N[C@@H](CC(N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCCN)C(N[C@]([C@@H](C)O)([H])C(N[C@H](C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CO)C3=O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CNC6=C5C=CC=C6)=O)CC7=CC=CC=C7)=O)CC8=CC=CC=C8)=O)=O)=O)CSSC[C@H](N3)C(O)=O)=O)=O)C)=O)=O)=O)=O)=O)=O)C)=O)CCSC)=O)C)=O)=O)=O)=O)=O)C)=O.FC(F)(C(O)=O)F
分子式C137H207N41O39S3• XCF3COOH
分子量3148.6
溶解度Formic Acid: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Somatostatin-28 is a cyclic neuropeptide hormone that has a role in endocrine regulation.1It is a somatostatin (SST) receptor agonist that binds to SST1, SST2, SST3, SST4, and SST5(IC50s = 0.60, 0.12, 0.22, 0.83, and 0.41 nM, respectively, in CCL39 cells expressing human recombinant receptors).2It inhibits cAMP accumulation induced by forskolin in CCL39 cells expressing human recombinant SST1, SST2, SST3, SST4, and SST5(EC50s = 5.13, 1.91, 6.46, 2.95, and 3.55 nM, respectively).3Somatostatin-28 stimulates growth hormone (GH) release from primary porcine pituitary cells when used at a concentration of 1 fM.4It inhibits acid secretion induced by gastrin I and IBMX in isolated rat gastric mucosa (EC50s = 27 and 252 nM, respectively).5In vivo, somatostatin-28 dose-dependently increases basal and pentagastrin-induced gastric acid secretion in rats.6

1.Lucey, M.R.Endogenous somatostatin and the gutGut27(4)457-467(1986) 2.Siehler, S., Seuwen, K., and Hoyer, D.Characterisation of human recombinant somatostatin receptors. 1. Radioligand binding studiesNaunyn Schmiedebergs Arch. Pharmacol.360(5)488-499(1999) 3.Siehler, S., and Hoyer, D.Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activityNaunyn Schmiedebergs Arch. Pharmacol.360(5)510-521(1999) 4.RamÍrez, J.L., Torronteras, R., CastaÑo, J.P., et al.Somatostatin plays a dual, stimulatory/inhibitory role in the control of growth hormone secretion by two somatotrope subpopulations from porcine pituitaryJ. Neuroendocrinol.9(11)841-848(1997) 5.Wyatt, M.A., Jarvie, E., Feniuk, W., et al.Somatostatin sst2 receptor-mediated inhibition of parietal cell function in rat isolated gastric mucosaBr. J. Pharmacol.119(5)905-910(1996) 6.Seefried, G., Schmidtler, J., and Schwille, P.O.Gastric secretion and gastrin under progressive doses of somatostatin-14 and -28 administered intraperitoneally to the ratPeptides9(2)249-255(1988)