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L-Homocysteic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Homocysteic acid图片
CAS NO:14857-77-3
包装:10mg
市场价:792元

产品介绍
L-Homocysteic acid (L-HCA) 是一种内源性兴奋性氨基酸,可作为 NMDA 受体激动剂 (EC50: 14 μM)。L-Homocysteic acid 具有神经毒性,可用于神经系统疾病的研究。
Cas No.14857-77-3
别名L-HCA
分子式C4H9NO5S
分子量183.18
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-Homocysteic acid (L-HCA) is an endogenous excitatory amino acid that acts as aNMDAreceptor agonist (EC50: 14 μM). L-Homocysteic acid is neurotoxic, and can be used in the research of neurological disorders[1][2][3].

L-Homocysteic acid activates NMDA receptor with an EC50value of 14 μM[1].
L-Homocysteic acid (100 μM) induces large currents (1.8 nA) that is insensitive to the NMDA receptor-antagonist mixture in Purkinje cells[1].
L-Homocysteic acid (250 μM, 30 min) potently induces an acute excitotoxic reaction inex vivochick embryo retina[2].
L-Homocysteic acid (0-2 mM, 48 h) induces a concentration-dependent neurotoxic effect in rat primary neurons[3].

L-Homocysteic acid (intraperitoneal injection, 4-11 mmol/kg) elicits seizures in rats during early postnatal development[4].
L-Homocysteic acid (intraperitoneal injection, 100-1500 mg/kg) partially substitutes for NMDA, producing maximum values of 61-67% NMDA-lever responding at doses of 1000 and 560 mg/kg, respectively in Sprague-Dawley rats[5].

Animal Model:Male albino rats of the Wistar strain[4]
Dosage:4, 5.5, 8, 11 mM/kg
Administration:Intraperitoneal injection, daily for 14 days
Result:Induced flexion seizures at 4 mmol/kg.
Led to intense tail flicking, pivoting, and locomotion.
Decreased ECoG (electrocorticograms) activity for 5-9 min.

[1]. M Yuzaki, et al. Characterization of L-homocysteate-induced currents in Purkinje cells from wild-type and NMDA receptor knockout mice. J Neurophysiol . 1999 Nov;82(5):2820-6.
[2]. J W Olney, et al. L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor. Brain Res Bull. 1987 Nov;19(5):597-602.
[3]. B Lockhart, et al. Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with alpha-lipoic acid enantiomers. Brain Res. 2000 Feb 14;855(2):292-7.
[4]. P Mares, et al. Convulsant action of D,L-homocysteic acid and its stereoisomers in immature rats.
[5]. Katherine L Nicholson, et al. The discriminative stimulus effects of N-methyl-D-aspartate glycine-site ligands in NMDA antagonist-trained rats. Psychopharmacology (Berl). 2009 Apr;203(2):441-51.