| CAS NO: | 2768759-64-2 |
| 包装: | 1mg |
| 市场价: | 1330元 |
| Cas No. | 2768759-64-2 |
| Canonical SMILES | O=C(NS(=O)(C1=CC(C(C)(O)C)=CO1)=O)[N-]C2=CC(C)=CC(C)=C2.[Na+] |
| 分子式 | C16H19N2O5S ? Na |
| 分子量 | 374.4 |
| 溶解度 | DMSO: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Inflammasome inhibitor 4b is an inhibitor of NOD-like receptor protein 3 (NLRP3) inflammasome activation.1It inhibits ATP-induced IL-1β release by 98.3% in LPS-primed mouse bone marrow-derived macrophages (BMDMs) when used at a concentration of 1 µM. Inflammasome inhibitor 4b (3 and 10 mg/kg) decreases paw swelling and mechanical hyperalgesia in a mouse model of gout induced by monosodium urate crystals. 1.Narros-FernÁndez, P., Chioua, M., Petcu, S.A., et al.Synthesis and pharmacological evaluation of new N-sulfonylureas as NLRP3 inflammasome inhibitors: Identification of a hit compound to treat goutJ. Med. Chem.65(8)6250-6260(2022) |
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