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Endothelin-1(1-15),amide,human
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Endothelin-1(1-15),amide,human图片
包装:1mg
市场价:4158元

产品介绍

Vasoconstrictor agent

别名H2N-Cys-Ser-Cys-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys-Val-Tyr-Phe-Cys-NH2
分子式C70H109N17O23S5
分子量1717.04
溶解度Soluble in water or 1% acetic acid
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium and have a key role in vascular homeostasis. Endothelin-1 is one of the there isoforms of endothelin (identified as ET-1, -2, -3) with varying regions of expression and binding to at least four known endothelin receptors, ETA, ETB1, ETB2 and ETC. [1]

Endothelins constrict blood vessels and raise blood pressure. They are normally kept in balance by other mechanisms, but when they are over-expressed, they contribute to high blood pressure (hypertension) and heart disease.

Endothelins are the most potent vasoconstrictors known. [2] In a healthy individual, a delicate balance between vasoconstriction and vasodilation is maintained by endothelin and other vasoconstrictors as well as nitric oxide, prostacyclin and other vasodilators. The ubiquitous distribution of endothelin peptides and receptors implicates its involvement in a wide variety of physiological and pathological processes in the body. Among numerous diseases potentially occurring from endothelin dysregulation are: several types of cancer [3], cerebral vasospasm following subarachnoid hemorrhage, arterial hypertension and other cardiovascular disorder, pain mediation, type II diabetes, etc.

References:
1. Medical physiology a cellular and molecular approach (2nd ed., International ed. ed.). Philadelphia, PA: Saunders/Elsevier. 2009. pp. 480.
2. Modern pharmacology with clinical applications (6th ed. ed.). Philadelphia: Lippincott Williams & Wilkins. 2004. pp. 215.
3. Bagnato A, Rosanò L (2008). "The endothelin axis in cancer". Int. J. Biochem. Cell Biol. 40 (8): 1443–51.