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GnRH Associated Peptide(GAP)(1-13),human
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GnRH Associated Peptide(GAP)(1-13),human图片
CAS NO:100111-07-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍

Inhibitor of prolactin secretion

Cas No.100111-07-7
别名H2N-Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-Val-OH
化学名GnRH Associated Peptide (GAP) (1-13), human
Canonical SMILESCCC(C)C(C(=O)NC(C(C)C)C(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C(CC1=CC=CC=C1)NC(=O)C(CO)NC(=O)C(CC(=O)O)NC(=O)C(C(C)CC)NC(=O)C(CC(C)C)NC(=O)C(CC(=O)N)NC(=O)C(CCC(=O)O)NC(=O)C(C)NC(=O)C(CC(=O)O)N
分子式C65H101N15O25
分子量1492.58
溶解度≥ 74.6mg/mL in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Sequence: Asp-Ala-Glu-Asn-Leu-Ile-Asp-Ser-Phe-Gln-Glu-Ile-Val

The cloned complementary DNA sequence encoding the human gonadotropin-releasing hormone (GnRH) precursor protein was used to construct an expression vector for the bacterial synthesis of the 56-amino acid GnRH-associated peptide (GAP). GAP was found to be a potent inhibitor of prolactin secretion and to stimulate the release of gonadotropins. Active immunization with peptides corresponding to GAP sequences led to greatly increased prolactin secretion.

Gonadotropin-releasing hormone (GnRH) is known and named for its essential role in vertebrate reproduction. Release of this decapeptide from neurons in the hypothalamus controls pituitary gonadotropin levels that, in turn, regulate the gonadal state. The importance of GnRH is underscored by its widespread expression and conservation across vertebrate taxa. Also, GnRH-associated peptide (GAP) is co-secreted with GnRH into the hypophyseal portal bloodstream.

References:
1. K?roly Nikolics,, Anthony J. Mason, ?va Sznyi, J. Ramachandran & Peter H. Seeburg, A prolactin-inhibiting factor within the precursor for human gonadotropin-releasing hormone, Nature 316, 511-517 (8 August 1985) doi:10.1038/316511a0
2. White SA, Kasten TL, Bond CT, Adelman JP, Fernald RD. Three gonadotropin-releasing hormone genes in one organism suggest novel roles for an ancient peptide. Proc Natl Acad SciUSA 92: 8363-8367, 1995.
3. Tianbao Song, Karoly Nikolics, Peter H. Seeburg, Paul C. Goldsmith, GnRH-prohormone-containing neurons in the primate brain: Immunostaining for the GnRH-Associated peptide, Peptides, Volume 8, Issue 2, March-April 1987, Pages 335-346
4. Ronchi E. ? Aoki C. ? Krey L.C. ? Pfaff D.W.
Immunocytochemical Study of GnRH and GnRH-Associated Peptide in Male Syrian Hamsters as a Function of Photoperiod and Gonadal Alterations, Neuroendocrinology 1992;55:134-145 (DOI:10.1159/000126108)
5. I.J. Clarke, J.T. Cummins, F.J. Karsch, P.H. Seeburg, K. Nikolics,GnRH-associated peptide (GAP) is cosecreted with GnRH into the hypophyseal portal blood of ovariectomized sheep, Biochemical and Biophysical Research Communications, Volume 143, Issue 2, 13 March 1987, Pages 665-671