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NGR peptide Trifluoroacetate
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
NGR peptide Trifluoroacetate图片
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
NGR peptide Trifluoroacetate 是含有天冬酰胺-甘氨酸-精氨酸 (NGR) 基序的肽，NGR peptide (NGR 肽) 可靶向肿瘤新生血管上皮细胞特异过量表达的 CD13 受体。
别名NGR肽三氟乙酸盐
分子式C22H37F3N10O10S2
分子量722.72
溶解度Water: ≥ 100 mg/mL (138.37 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

NGR peptide Trifluoroacetate containing the asparagine-glycine-arginine (NGR) motif is recognized by CD13/aminopeptidase N (APN) receptor isoforms that are selectively overexpressed in tumor neovasculature. CD13/aminopeptidase N (APN) receptor[1]

NGR peptide can selectively bind to APN/CD13 either immune-captured or expressed on the surface of cells, the receptor of the tumor-homing NGR peptide was suspected to be APN/CD13. The NGR peptide is reported to have the greatest tumor selectivity. An anti-cancer drug Doxorubicin (DOX) coupled to an NGR peptide displays enhanced anti-tumor effects with even lower toxicity than the free drug itself[2].

NGR peptide imaging in vivo not only provides more insight into NGR's targeting process, including bio-distribution and pharmacokinetics, but also reveals angiogenic activities related to tumor progression and malignancy[2].

[1]. Enyedi KN, et al. NGR-peptide-drug conjugates with dual targeting properties. NGR-peptide-drug conjugates with dual targeting properties. [2]. Wang RE, et al. Development of NGR peptide-based agents for tumor imaging. Am J Nucl Med Mol Imaging. 2011;1(1):36-46.