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β-Aescin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
β-Aescin图片
CAS NO:11072-93-8
包装与价格：
包装价格(元)
500mg电议
1 g电议
5 g电议

产品介绍
A triterpenoid saponin with diverse biological activities
Cas No.11072-93-8
别名beta-七叶素
Canonical SMILESCC1(C)[C@@H](OC(C(C)=CC)=O)[C@H](OC(C)=O)[C@]2(CO)[C@H](O)C[C@@]3(C)[C@]4(C)CC[C@@]5([H])[C@@](C)(CO)[C@@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O)[C@H](O)[C@H]8O)[C@@H](C(O)=O)O6)CC[C@]5(C)[C@@]4([H])CC=C3[C@]2([H])C1
分子式C55H86O24
分子量1131.3
溶解度DMF: 1 mg/ml,DMSO: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

β-Aescin is a triterpenoid saponin that has been found inA. hippocastanumand has diverse biological activities.1,2,3,4It inhibits the proliferation of QBC939, SK-ChA-1, and Mz-ChA-1 cholangiocarcinoma cells (IC50s = 34.06, 33.3, and 22.1 µM, respectively).1β-Aescin inhibits herpes simplex virus 1 (HSV-1) infection in Vero cells (EC50s = 1.9-2.4 µg/ml).2It increases contraction tension in isolated dog saphenous vein strips in a concentration-dependent manner.3β-Aescin (10 mg/kg) reduces brain edema in a rat model of traumatic brain injury.4

1.Shen, D.-Y., Kang, J.-H., Song, W., et al.Apoptosis of human cholangiocarcinoma cell lines induced by β-escin through mitochondrial caspase-dependent pathwayPhytother. Res.25(10)1519-1526(2011) 2.Michelini, F.M., AlchÉ, L.E., and Bueno, C.A.Virucidal, antiviral and immunomodulatory activities of β-escin and Aesculus hippocastanum extractJ. Pharm. Pharmacol.70(11)1561-1571(2018) 3.Yu, Z., and Su, P.Effect of β-aescin extract from Chinese buckeye seed on chronic venous insufficiencyPharmazie68(6)428-430(2013) 4.Xiao, G., and Wei, J.Effects of β-aescin on the expression of nuclear factor-κβ and tumor necrosis factor-α after traumatic brain injury in ratsJ. Zhejiang. Univ. Sci. B.6(1)28-32(2005)