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β-Rubromycin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
β-Rubromycin图片
CAS NO:27267-70-5
包装与价格：
包装价格(元)
1mg电议
5mg电议

产品介绍
β-Rubromycin 是人类免疫缺陷病毒-1 (HIV-1) RNA 导向的 DNA 聚合酶（逆转录酶）的有效选择性抑制剂。
Cas No.27267-70-5
别名BETA-玉红霉素
Canonical SMILESO=C(OC)C(O1)=CC(C=C(CC[C@@]2(OC(C(C(C(O)=C(OC)C=C3OC)=C3C4=O)=O)=C4C2)O5)C5=C6O)=C6C1=O
分子式C27H20O12
分子量536.4
溶解度DMSO: 1 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

β-Rubromycin is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities.1 It inhibits the growth of HMO2, KATO-III, and MCF-7 cells with GI50 values of 0.5, 0.84, and<0.1 μM, respectively. β-rubromycin inhibits HIV-1 reverse transcriptase activity by 39.7% when used at a concentration of 10 μM. It also has antibacterial activity against Gram-positive bacteria. The structure of β-rubromycin was originally described as containing an ortho-quinone group, but it was revised to a para-quinone group in 2000 using organic and biosynthetic methods, as well as spectroscopic analysis.1,2,3

References
1. Ueno, T., Takahashi, H., Oda, M., et al. Inhibition of human telomerase by rubromycins: Implication of spiroketal system of the compounds as an active moiety. Biochemistry 39(20), 5995-6002 (2000).
2. Puder, C., Loya, S., Hizi, A., et al. Structural and biosynthetic investigations of the rubromycins. Eur. J. Org. Chem. 2000(5), 729-735 (2000).
3. Goldman, M.E., Salituro, G.S., Bowen, J.A., et al. Inhibition of human immunodeficiency virus-1 reverse transcriptase activity by rubromycins: Competitive interaction at the template.primer site. Mol. Pharmacol. 38(1), 20-25 (1990).