(±)9(10)-DiHOME 是 9,10-DiHOME 的外消旋体。
| Cas No. | 263399-34-4 |
| 别名 | (±)-苏式-9,10-二羟基-12(Z)-十八碳烯酸 |
| Canonical SMILES | O[C@H](C/C=C\CCCCC)[C@@H](O)CCCCCCCC(O)=O |
| 分子式 | C18H34O4 |
| 分子量 | 314.5 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 10 µ g/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Leukotoxin is the 9(10) epoxide of linoleic acid, generated by neutrophils during the oxidative burst. This unstable compound is rapidly degraded by epoxide hydrolases to form the diol, (±)9(10)-DiHOME. Mitochondrial dysfunction, vasodilation, and apoptosis are features of leukotoxin toxicity. In renal proximal tubular cells, the diol hydrolysis products of leukotoxin, such as (±)9(10)-DiHOME, have been directly implicated as the cytotoxic agent responsible for cell death. |
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