| CAS NO: | 748778-73-6 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 748778-73-6 |
| 分子式 | C12H7ClO2S2 |
| 分子量 | 282.77 |
| 溶解度 | DMSO : 100 mg/mL (353.64 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | YC-001 is an inverse agonist and antagonist of rod opsin. YC-001 reversibly binds rod opsin and stabilizes the rod opsin structure. YC-001 protects mice from bright light-induced retinal degeneration. YC-001 has the potential for the research of retinal degeneration[1]. YC-001 (0-100 µM) shows a potency activity of 8.7 µM and an efficacy at 150-310%[1].YC-001 (0.5, 1, 5, 10, 20, 40 µM) improves the glycosylation profile of P23H opsin mutant[1].YC-001 (0,-1.5 µM) reversibly binds rod opsin with EC50 OF 0.98 µM[1].YC-001 (0.313, 0.625, 1.25, 2.5, 5, 10, 20, 80 µM) increases in cAMP level in a dose-dependent manner in NIH3T3 cells[1]. YC-001 (50, 200mg/kg; i.p.) protects Abca4-/-Rdh8-/- mice from bright light-induced retinal degeneration[1].YC-001 (200mg/kg; i.p.) enters mouse eyes after systemic administration but is not retained for prolonged periods[1].YC-001 (100 mg/kg, 200 mg/kg; i.p.; daily for 24 days) shows virtually no acute toxicity[1]. [1]. Chen Y, et al. A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration. Nat Commun. 2018 May 17;9(1):1976. |
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