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Ubiquitination-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ubiquitination-IN-1图片
CAS NO:1819330-15-8
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Ubiquitination-IN-1 (compound 24) 是泛素化 (ubiquitination) 和 Cksl-Skp2 蛋白互作抑制剂 (IC50=0.17 μM) 抑制剂，增加 p27 水平。Ubiquitination-IN-1 可通过阻断肿瘤抑制因子的降解来用于疾病。
Cas No.1819330-15-8
分子式C21H14F3N3O2S
分子量429.41
溶解度DMSO : 83.33 mg/mL (194.06 mM; ultrasonic and warming and heat to 60℃)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ubiquitination-IN-1 (compound 24) is a ubiquitination and Cksl-Skp2 protein-protein interaction (IC50=0.17 μM) inhibitor. Ubiquitination-IN-1 increases levels of p27. Ubiquitination-IN-1 has the potential for treatment disease by blocking the degradation of tumor suppressors[1].

Ubiquitination-IN-1 inhibits A549 and HT1080 cells with IC50s of 0.91 and 0.4 μM, respectively[1].

[1]. David Carroll, et al.Quinoline derivatives useful as ubiquitination inhibitors. WO2016025779A1.