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Difopein TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
包装:1mg
市场价:8820元

产品介绍
Difopein (TFA) 是 14-3-3 protein (一种高度保守的真核调节分子) 的特异性竞争性抑制剂,可阻止 14-3-3 与靶蛋白结合的能力,并抑制 14-3-3/配体的相互作用。Difopein (TFA) 诱导细胞凋亡 (apoptosis) 并增强顺铂杀死细胞的能力。
分子式C275H425N76F3O91S6
分子量6501.19
储存条件-20°C, away from moisture
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Difopein (TFA), a specific and competitive inhibitor of 14-3-3 protein (a highly conserved eukaryotic regulatory molecule), blocking the ability of 14-3-3 to bind to target proteins and inhibits 14-3-3/Ligand interactions. Difopein (TFA) leads to induction of apoptosis and enhances the ability of cisplatin to kill cells[1].

[1]. Masters SC, et al. 14-3-3 proteins mediate an essential anti-apoptotic signal. J Biol Chem. 2001 Nov 30;276(48):45193-200. Epub 2001 Sep 27.