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Celecoxib Carboxylic Acid
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Celecoxib Carboxylic Acid图片
CAS NO:170571-01-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
An inactive metabolite of celecoxib
Cas No.170571-01-4
别名羧酸塞来昔布
Canonical SMILESFC(F)(C1=NN(C2=CC=C(C=C2)S(=O)(N)=O)C(C(C=C3)=CC=C3C(O)=O)=C1)FFC(F)(C1=NN(C2=CC=C(C=C2)S(=O)(N)=O)C(C(C=C3)=CC=C3C(O)=O)=C1)F
分子式C17H12F3N3O4S
分子量411.4
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:6): 0.12 mg/ml,PBS (pH 7.2): slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Celecoxib carboxylic acid is an inactive metabolite of the COX-2 inhibitor celecoxib .1,2It is formed from celecoxib primarily by the cytochrome P450 (CYP) isoform CYP2C9.

1.Liu, H., Huang, X., Shen, J., et al.Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: Molecular docking and 3D QSAR analysesJ. Med. Chem.45(22)4816-4827(2002) 2.Kim, S.-H., Kim, D.-H., Byeon, J.-Y., et al.Effects of CYP2C9 genetic polymorphisms on the pharmacokinetics of celecoxib and its carboxylic acid metaboliteArch. Pharm. Res.40(3)382-390(2017)