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Hydroxy Celecoxib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hydroxy Celecoxib图片
CAS NO:170571-00-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
An inactive metabolite of celecoxib
Cas No.170571-00-3
别名羟甲基塞来昔布
Canonical SMILES2935.90.9550NS(C1=CC=C(N2C(C3=CC=C(CO)C=C3)=CC(C(F)(F)F)=N2)C=C1)(=O)=O
分子式C17H14F3N3O3S
分子量397.4
溶解度DMSO: slightly soluble,Methanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hydroxy celecoxib is an inactive metabolite of celecoxib .1It is formed from celecoxib by the cytochrome P450 (CYP) isoforms CYP2C9, CYP3A4, and CYP2D6 in human liver microsomes.2

1.Penning, T.D., Talley, J.J., Bertenshaw, S.R., et al.Synthesis and biological evaluation fo the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: Identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, celecoxib)J. Med. Chem.40(9)1347-1365(1997) 2.Siu, Y.A., Hao, M.-H., Dixit, V., et al.Celecoxib is a substrate of CYP2D6: Impact on celecoxib metabolism in individuals with CYP2C9*3 variantsDrug Metab. Pharmacokinet.33(5)219-227(2018)