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Cobaltic Protoporphyrin IX(chloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cobaltic Protoporphyrin IX(chloride)图片
CAS NO:102601-60-5
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
An inducer of HO-1 activity
Cas No.102601-60-5
别名原卟啉氯化钴
Canonical SMILES[Cl-][Co+3]1([N](C2=C3)=C(C(C=C)=C2C)C=C4C(C)=C5CCC([O-])=O)([N-]6C3=C7C=C)[N-]4C5=CC(C(CCC([O-])=O)=C8C)=[N]1C8=CC6=C7C.[H+].[H+]
分子式C34H30ClCoN4O4·2H
分子量655
溶解度DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:6): 0.14 mg/ml,DMSO: 25 mg/ml,Ethanol: 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cobaltic protoporphyrin IX is a metalloporphyrin and an inducer of heme oxygenase-1 (HO-1) activity.1Unlike other metalloporphyrins, cobaltic protoporphyrin IX induces activity of HO-1, the rate-limiting enzyme in heme catabolism,in vitroandin vivo.1,2It also reduces the activity of δ-aminolevulinate synthase, the enzyme that catalyzes the rate-limiting step of heme biosynthesis, as well as decreases the activity of cytochrome P450 (CYP), in rat liver microsomesex vivowhen administered at a dose of 125 µmol/kg.2Cobaltic protoporphyrin IX (5 mg/kg) prevents liver injury and increases in the percentage of hepatic apoptotic cells in a mouse model of liver ischemia-reperfusion injury.3It increases survival and decreases the number of lung colony forming units (CFUs) in mice infected withY. pestisat the same dose.4Cobaltic protoporphyrin IX has also been used as a catalyst for the electrochemical reduction of carbon dioxide in carbon electrodes.5

1.Shan, Y., Lambrecht, R.W., Donohue, S.E., et al.Role of Bach1 and Nrf2 in up-regulation of the heme oxygenase-1 gene by cobalt protoporphyrinFASEB J.20(14)2651-2653(2006) 2.Drummond, G.S., and Kappas, A.The cytochrome P-450-depleted animal: An experimental model for in vivo studies in chemical biologyProc. Natl. Acad. Sci. USA79(7)2384-2388(1982) 3.Li, J., Wu, B., Teng, D., et al.Cobalt-protoporphyrin enhances heme oxygenase 1 expression and attenuates liver ischemia/reperfusion injury by inhibiting apoptosisMol. Med. Rep.17(3)4567-4572(2018) 4.Willix, J.L., Stockton, J.L., Olson, R.M., et al.Activation of heme oxygenase expression by cobalt protoporphyrin treatment prevents pneumonic plague caused by inhalation of Yersinia pestisAntimicrob. Agents Chemother.64(4)e01819-01819(2020) 5.Shen, J., Kortlever, R., Kas, R., et al.Electrocatalytic reduction of carbon dioxide to carbon monoxide and methane at an immobilized cobalt protoporphyrinNat. Commun.68177(2015)