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Tebuconazole-d9
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tebuconazole-d9图片
CAS NO:1246818-83-6
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of tebuconazole
Cas No.1246818-83-6
别名戊唑醇 d9
Canonical SMILESClC(C=C1)=CC=C1CCC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])(O)CN2C=NC=N2
分子式C16H13ClD9N3O
分子量316.9
溶解度Acetonitrile: soluble,DMSO: soluble,Methanol: soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tebuconazole-d9is intended for use as an internal standard for the quantification of tebuconazole by GC- or LC-MS. Tebuconazole is a triazole fungicide that is active against both seed and foliar fungi.1It inhibits 14α-demethylase isolated fromU. maydisandS. bicolorwith IC50values of 0.05 and 0.16 nM, respectively.2It inhibits the androgenic effect of the androgen receptor agonist DHT (IC20= 2.89 µM) and is cytotoxic (EC20= 38.9 µM) in an MDA-kb2 assay.3Tebuconazole (50 and 100 mg/kg per day) administered during gestation reduces testosterone levels and increases testicular levels of progesterone and 17α-hydroxyprogesterone in male rat fetuses.4It has a feminizing effect on male pups and a virilizing effect on female pups. When administered to rats gestationally through postnatal day 42, tebuconazole (20 and 60 mg/kg per day) leads to cell death of pyramidal cells in the CA3-4 region of the hippocampus and layer V of the cortex concomitant with impairment in learning the platform location in the Morris water maze.5

1.Reinecke, P., Kaspers, H., Scheinpflug, H., et al.BAY HWG 1608, a new fungicide for foliar spray and seed-treatment use against a wide spectrum of fungal pathogensBr. Crop Prot. Conf.--Pests Dis., Proc. 141-46(1986) 2.Zarn, J.A., BrÜschweiler, B.J., and Schlatter, J.R.Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 α-demethylase and aromataseEnviron. Health Perspect.111(3)255-261(2003) 3.Orton, F., Rosivatz, E., Scholze, M., et al.Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogensEnviron. Health Perspect.119(6)794-800(2011) 4.Taxvig, C., Hass, U., Axelstad, M., et al.Endocrine-disrupting activities in vivo of the fungicides tebuconazole and epoxiconazoleToxicol. Sci.100(2)464-473(2007) 5.Moser, V.C., Barone, S., Jr., Smialowicz, R.J., et al.The effects of perinatal tebuconazole exposure on adult neurological, immunological, and reproductive function in ratsToxicol. Sci.62(2)339-352(2001)