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Phenethyl isothiocyanate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Phenethyl isothiocyanate图片
CAS NO:2257-09-2
包装与价格:
包装价格(元)
50 g电议
100 g电议

产品介绍
An isothiocyanate with anticancer activity
Cas No.2257-09-2
别名2-苯基乙基异硫代氰酸酯
Canonical SMILESS=C=NCCC1=CC=CC=C1
分子式C9H9NS
分子量163.2
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Phenethyl isothiocyanate (PEITC) is an isothiocyanate that has been found in cruciferous vegetables and has anticancer activity.1It inhibits the activity of glutathione peroxidase (GPX), reduces cellular glutathione (GSH) levels, and induces the accumulation of reactive oxygen species (ROS) in T72 ovarian epithelial cells expressing H-RasV12when used at a concentration of 10 µM.2PEITC (10 µM) induces cell cycle arrest at the G2/M phase and apoptosis in PL45, MIA PaCa-2, and BxPC-3 pancreatic cancer cells.3It decreases the number of tumor cells expressing Ki-67 or proliferating cell nuclear antigen (PCNA), markers of cell proliferation, and reduces tumor growth in a MIA PaCa-2 mouse xenograft model.

1.Gupta, P., Wright, S.E., Kim, S.-H., et al.Phenethyl isothiocyanate: A comprehensive review of anti-cancer mechanismsBiochim. Biophys. Acta1846(2)405-424(2014) 2.Trachootham, D., Zhou, Y., Zhang, H., et al.Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanateCancer Cell10(3)241-252(2006) 3.Stan, S.D., Singh, S.V., Whitcomb, D.C., et al.Phenethyl isothiocyanate inhibits proliferation and induces apoptosis in pancreatic cancer cells in vitro and in a MIAPaca2 xenograft animal modelNutr. Cancer66(4)747-755(2014)