| 包装: | 5mg |
| 市场价: | 6300元 |
| 分子式 | C32H42N6O3 |
| 分子量 | 558.71 |
| 溶解度 | DMSO : 80 mg/mL (143.19 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | UZH1a is a potent and selective METTL3 inhibitor, with an IC50 of 280 nM. UZH1a can be used for epitranscriptomic modulation of cellular processes. UZH1a has antitumor activity. UZH1a also can be used as a chemical probe for studying METTL3[1]. UZH1a (2.5-160 µM; 72 h) inhibits the growth of MOLM-13, HEK293T, and U2Os cells, with IC50s of 11 µM, 67 µM, and 87 µM, respectively[1].UZH1a (2.5-100 µM; 16 h) reduces m6A methylation level in mRNA from MOLM-13 cells in a dose-dependent manner (IC50=4.6 µM)[1].UZH1a (40 µM; 16 h) reduces m6A methylation level in mRNA from MOLM-13, HEK293T, and U2Os cells[1].UZH1a (20 µM; 16 h) increases apoptosis and leads to cell cycle arrest in MOLM-13 cells[1]. [1]. Moroz-Omori EV, et, al. METTL3 inhibitors for epitranscriptomic modulation of cellular processes. bioRxiv. 2020 Oct 13. |
m.cnreagent.com