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Menin-MLL inhibitor 20
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Menin-MLL inhibitor 20图片
CAS NO:2448173-47-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Menin-MLL inhibitor 20 是一种不可逆的 menin-MLL 相互作用的抑制剂,具有抗肿瘤活性 (WO2020142557A1, compound 6)。
Cas No.2448173-47-3
分子式C33H40N8O4
分子量612.72
溶解度DMSO : 33.33 mg/mL (54.40 mM; ultrasonic and warming and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Menin-MLL inhibitor 20 is an irreversible menin-MLL interaction inhibitor with antitumor activities (WO2020142557A1, compound 6)[1].

The Histone-lysine N-methyltransferase 2 (KMT2) family of proteins, which currently consists of at least 5 members, methylate ly sine 4 on the histone H3 tails at important regulatory regions in the genome and thereby impart crucial functions through the modulation of chromatin structures and DNA accessibility. These enzymes are known to play an important role in the regulation of gene expression during early development and hematopoiesis. The human KMT2 family was initially named the mixed-lineage leukaemia (MLL) family, owing to the role of the first-found member in this disease[1].

[1]. Thomas Butler, et al. Irreversible inhibitors of menin-mll interaction. WO2020142557A1.