CAS NO: | 1639009-81-6 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
Cas No. | 1639009-81-6 |
Canonical SMILES | O=C(NC1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(NC3=NC(NC4=NNC(C5CCCC5)=C4)=CC=N3)C=C2 |
分子式 | C26H25F3N8O |
分子量 | 522.5 |
溶解度 | Ethanol: soluble |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | CD532 is an inhibitor of Aurora A kinase activity (IC50= 48 nM) and the protein-protein interaction between N-Myc and Aurora A kinase.1It also inhibits several cyclin-dependent kinases (CDKs), FGFRs, MEKs, and PDGFRs, as well as FLT3, KIT, and RET at 10 µM.2CD532 induces degradation of N-Myc in SK-N-BE(2) neuroblastoma cells (EC50= 223 nM).1It prevents S-phase entry in SK-N-BE(2) cells when used at a concentration of 1 µM.1CD532 (25 mg/kg) reduces tumor growth and increases survival in aMYCN-amplified SMS-KCN neuroblastoma mouse xenograft model. 1.Gustafson, W.C., Meyerowitz, J.G., Nekritz, E.A., et al.Drugging MYCN through an allosteric transition in Aurora kinase ACancer Cell26(3)414-427(2014) 2.Lee, J.K., Phillips, J.W., Smith, B.A., et al.N-Myc drives neuroendocrine prostate cancer initiated from human prostate epithelial cellsCancer Cell29(4)536-547(2016) |