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PFI-90
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PFI-90图片
CAS NO:53995-62-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
PFI-90 是一种组蛋白去甲基化酶 (KDM3B) 选择抑制剂,可抑制 PAX3-FOXO1 的作用。PFI-90 可诱导细胞凋亡和肌源性分化,导致细胞死亡的增加。PFI-90 具有潜在的抗肿瘤活性,来自专利 WO2021101929A1。
Cas No.53995-62-3
别名N'-(吡啶-2-基)吡啶-2-甲酰肼
分子式C11H10N4O
分子量214.22
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).

PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μμ; 24 hours) increases apoptosis in RH4 and SCMC cells[1].

[1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.